Discussing the Strehler-Mildvan model of mortality

Aging: damage accumulation versus increasing mortality rate.

If aging is understood as some process of damage accumulation, it does not necessarily lead to increasing mortality rate. Within the framework of a suggested generalization of the Strehler-Mildwan (1960) [B.L. Strehler, A.S. Mildvan (1960). General theory of mortality and aging, Science, 132, 14] model, we show that even for models with monotonically increasing degradation, the mortality rate c...

Vitality heterogeneity in the Strehler-Mildvan theory of mortality.

In this paper the Strehler-Mildvan theory of mortality and aging is generalised to cover heterogeneity effects in the population. The theory is based on the concept of environmental shocks that cause death of an individual when exceeding its vitality. Heterogeneity is introduced via the value of the vitality of an individual at birth. The main result of the paper is an expression for the observ...

Study on Robustness of Strehler-mildvan Model

Heterogeneity in the Strehler-Mildvan general theory of mortality and aging.

This study examines and further develops the classic Strehler-Mildvan (SM) general theory of mortality and aging. Three predictions from the SM theory are tested by examining the age dependence of mortality patterns for 42 countries (including developed and developing countries) over the period 1955-2003. By applying finite mixture regression models, principal component analysis, and random-eff...

Properties of a Stochastic Model for Life Table Data: Exploring Life Expectancy Limits

In this paper we explore the life expectancy limits by based on the stochastic modeling of mortality and applying the first exit or hitting time theory of a stochastic process. The main assumption is that the health state or the “vitality”, according to Strehler and Mildvan, of an individual is a stochastic variable and thus it was introduced and applied a first exit time density function to mo...